Back to the stack

Principal Enterprise Architect, Digital Solutions 2 Locations

Remote Worldwide Hiring now

McKesson is an impact-driven, Fortune 10 company that touches virtually every aspect of healthcare. We are known for delivering insights, products, and services that make quality care more accessible and affordable. Here, we focus on the health, happiness, and well-being of you and those we serve – we care. What you do at McKesson matters. We foster a culture where you can grow, make an impact, and are empowered to bring new ideas. Together, we thrive as we shape the future of health for patients, our communities, and our people. If you want to be part of tomorrow’s health today, we want to hear from you. Role Summary: The Principal Enterprise Architect, Digital Solutions is a senior leader responsible for defining and advancing the enterprise digital architecture strategy that enables scalable, secure, and innovative digital solutions for US Oncology Practices. This role partners closely with executive leaders, business stakeholders, clinical teams, and technology teams to translate Practice strategy into cohesive architectural direction. Key Role Success Metrics:

  • Unified enterprise architecture blueprint established and regularly updated as needed.
  • Multi-year digital roadmap delivered and socialized, with regular updates as needed.
  • Architecture governance adopted across teams.
  • Modernization and interoperability improvements realized.

Key Responsibilities:

  • Define and evolve the enterprise digital architecture vision, principles, and roadmaps aligned with business objectives.
  • Provide architectural leadership for major digital initiatives, platform strategies, and transformation programs.
  • Advise executives and senior leaders on technology trends, risks, and long-term architectural implications.
  • Ensure digital solutions are secure, scalable, interoperable, and compliant with enterprise and regulatory standards.
  • Establish and maintain reference architectures, patterns, and governance.
  • Influence and mentor architects and technical leaders through thought leadership.

Role Characteristics:

  • Enterprise-wide scope with significant strategic and technical influence.
  • Operates effectively in highly complex and ambiguous environments.
  • Combines deep technical expertise with business and strategic acumen.
  • Recognized authority for digital architecture and cross-domain design decisions.

Minimum Qualifications:

  • Degree or equivalent and typically requires 13+ years, with 8+ years, of direct work[1]related experience. Less years required if has relevant Masters or Doctorate qualifications.

Critical Experience/Skills:

  • Extensive experience in enterprise architecture or engineering leadership roles.
  • Expertise in cloud modernization, multi-tenant platforms, and large-scale system design.
  • Strong integration architecture background with APIs and interoperability standards.
  • Experience with data platforms, semantic layers, analytics, and governed access models.
  • Familiarity with clinical systems and oncology digital workflows preferred.

Preferred Experience/Skills:

  • Experience in oncology, clinical operations, or life sciences.
  • Certifications: TOGAF, AWS/Azure Architect.
  • Experience applying AI/ML to enterprise digital solutions, defining AI platform standards, and familiarity with cloud‑native AI services.

Travel:

  • Up to 25% travel.

We are proud to offer a competitive compensation package at McKesson as part of our Total Rewards. This is determined by several factors, including performance, experience and skills, equity, regular job market evaluations, and geographical markets. The pay range shown below is aligned with McKessons pay philosophy, and pay will always be compliant with any applicable regulations. In addition to base pay, other compensation, such as an annual bonus or long-term incentive opportunities may be offered. For more information regarding benefits at McKesson, please click here. Our Base Pay Range for this position $178,800 - $298,000 McKesson has become aware of online recruiting-related scams in which individuals who are not affiliated with or authorized by McKesson are using McKesson’s (or affiliated entities, like CoverMyMeds or RxCrossroads) name in fraudulent emails, job postings or social media messages. In light of these scams, please bear the following in mind: McKesson Talent Advisors will never solicit money or credit card information in connection with a McKesson job application. McKesson Talent Advisors do not communicate with candidates via online chatrooms or using email accounts such as Gmail or Hotmail. Note that McKesson does rely on a virtual assistant (Gia) for certain recruiting-related communications with candidates. McKesson job postings are posted on our career site: careers.mckesson.com. McKesson is an Equal Opportunity Employer McKesson provides equal employment opportunities to applicants and employees, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, age, genetic information, or any other legally protected category. For additional information on McKesson’s full Equal Employment Opportunity policies, visit our Equal Employment Opportunity page. Join us at McKesson! Apply tot his job Apply To this Job

Apply for this role Opens the employer's application page — free, no JobStack account needed.

More from the stack

Principal Enterprise Architect (Public Sector)

Remote Worldwide
View role

Principal Enterprise Architect (Remote)

Remote Worldwide
View role

Sr. Customer Success Manager - Enterprise

Remote Worldwide
View role

Enterprise Account Executive: K-12

Remote Worldwide
View role

Enterprise Customer Success Manager – SLED Central at blithequark

Remote Worldwide
View role

Enterprise Account Executive (North America, EST, Remote)

Remote Worldwide
View role

Enterprise Data Architect – Governance & Cloud – (Remote in Pittsburgh)

Remote Worldwide
View role

Director Business Risk & Controls Advisory - Enterprise Data

Remote Worldwide
View role

Murex Consultant - S4C,FrontOffice,Enterprise Risk

Remote Worldwide
View role

Director | Enterprise Risk Management

Remote Worldwide
View role

Home Based Data Entry Jobs For House Wife and College Students

Remote Worldwide
View role

Remote Online Data Entry Work From Home Entry Level Opportunity at arenaflex

Remote Worldwide
View role

Site Reliability Engineer On Prem Storage Ohio

Remote Worldwide
View role

Immediate Hiring: Python Data Analyst

Remote Worldwide
View role

Citi Commercial Bank - Mid-Corp Relationship Manager, Digital Tech & Comms - Director

Remote Worldwide
View role

911 Call Taker I

Remote Worldwide
View role

Experienced Chat Specialist – Customer Service Representative – arenaflex

Remote Worldwide
View role

Associate Financial Planner

Remote Worldwide
View role

Software Engineer Level 3

Remote Worldwide
View role

Experienced Customer Service Representative – Delivering Exceptional Support in a Dynamic E-commerce Environment at arenaflex

Remote Worldwide
View role